GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7027110 | 1 | rs7027110 | chr9:109599046 | ZNF462 | chr9:109625378-109773789:+ | -0.11 | -3.84 | 0.000137 | Height |
| THCA | cis | rs10760706 | 1 | rs7027619 | chr9:102719728 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.35 | 1.63E-5 | Alopecia areata |
| THCA | cis | rs10760706 | 1 | rs7027813 | chr9:102675372 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.29 | 2.17E-5 | Alopecia areata |
| THCA | cis | rs965513 | 1 | rs7028661 | chr9:100538470 | C9orf156 | chr9:100666772-100684852:- | 0.13 | 3.39 | 0.000753 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs7029536 | 1 | rs7029536 | chr9:130110411 | SLC2A8 | chr9:130159465-130170161:+ | -0.13 | -3.48 | 0.000549 | Metabolite levels (HVA) |
| THCA | cis | rs965513 | 1 | rs7030241 | chr9:100550375 | C9orf156 | chr9:100666772-100684852:- | 0.14 | 3.69 | 0.000248 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs965513 | 1 | rs7030256 | chr9:100535203 | C9orf156 | chr9:100666772-100684852:- | 0.14 | 3.85 | 0.000135 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs965513 | 1 | rs7030280 | chr9:100535267 | C9orf156 | chr9:100666772-100684852:- | 0.14 | 3.86 | 0.000131 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs755109 | 1 | rs7030887 | chr9:100688511 | C9orf156 | chr9:100666772-100684852:- | -0.14 | -3.65 | 0.000296 | Quantitative traits |
| THCA | cis | rs755109 | 1 | rs7030907 | chr9:100688577 | C9orf156 | chr9:100666772-100684852:- | -0.14 | -3.65 | 0.000296 | Quantitative traits |
| THCA | cis | rs965513 | 1 | rs7032019 | chr9:100548144 | C9orf156 | chr9:100666772-100684852:- | 0.13 | 3.6 | 0.000349 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | cis | rs10816533 | 1 | rs7032889 | chr9:99621802 | FAM22G | chr9:99690592-99704572:+ | 0.93 | 8.57 | 1.42E-16 | Height |
| THCA | cis | rs10816533 | 1 | rs7032889 | chr9:99621802 | HIATL2 | chr9:99695549-99775862:- | 0.68 | 6.2 | 1.19E-9 | Height |
| THCA | cis | rs10816533 | 1 | rs7032889 | chr9:99621802 | LOC441454 | chr9:99671357-99672736:+ | 0.36 | 3.6 | 0.000358 | Height |
| THCA | cis | rs7849270 | 1 | rs7036114 | chr9:131893406 | CRAT | chr9:131857075-131873070:- | 0.28 | 6.86 | 2.15E-11 | Blood metabolite ratios |